Spherix is browser based simulation software for 3D tissue engineering. It predicts how oxygen reaches the cells inside a spheroid, and where cells become starved of oxygen or die.
Spherix is soon to be deployed. Early access is by contacting the team through the contact form.
A spheroid is a small ball of cells grown in the lab. Every change to its size, cell type or oxygen level normally means another 7 to 14 day culture, just to see whether the centre survives.
Powerful simulation tools exist. They are either priced for large pharma, or they require programming, installation and specialist knowledge. Spherix makes that capability usable in a web browser.
A live 3D spheroid adds or removes cells as the size changes, and you get an instant estimate as you move the sliders. Then run a full simulation and step through time on the finished run.
Every result comes with a 90% uncertainty range. Every prediction corresponds to a lab assay you already run, such as live/dead imaging, histology, hypoxia staining and oxygen probes, so it can be checked experimentally.
About 9 pages, designed to be sent to collaborators or reviewers as it is.
No installation, no code, no parameter files.
An analytical estimate updates while you adjust the parameters, with a live 3D spheroid that adds or removes cells as the size changes.
An agent based simulation built on PhysiCell follows every individual cell as it grows, divides, consumes oxygen and dies. Before you submit, Spherix estimates how long the run will take and suggests the nearest settings if it would be too large.
Rotate, cut open to see the zones inside, hover on any cell to read its oxygen level, and step through time on completed runs.
About 9 pages for every run, with inputs, sources, validation status and limitations, ready to send as it is.
Save parameter sets and past runs, and use the Compare view to set designs side by side.
See what the model has, and has not, been tested against.
Honest status. The dermal fibroblast model is data anchored and awaiting direct validation. Its inputs come from published measurements, and its predictions are consistent with published observations of dermal fibroblast spheroids, but no published dataset yet measures the inside of these spheroids directly. Spherix is for research use only. It is not for clinical, diagnostic or regulatory decisions.
Tissue engineering and organoid labs.
Teams working on 3D cell culture, scaffolds or cell therapy manufacturing.
Groups that cannot afford enterprise simulation software, or do not have computational staff to run open source simulators.
Large pharma has in house and enterprise simulation tools. Spherix serves the labs and small biotechs those tools are not built or priced for. It is a decision support tool for ranking and narrowing designs before wet lab work, not a replacement for experiments.
Seed cells and watch the centre starve. This is the problem Spherix puts on screen.
Spherix deploys in the cloud over HTTPS, or on a customer’s own server for labs that need their data to stay in house.
This version models oxygen. It does not model vascularisation, drug testing or other nutrients.
Early access is by contacting the team through the contact form. Tell us about your work and what you would like to test.